Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity).
Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2+ stores.
Is not required for early steps during B cell differentiation in the blood marrow.
Required for normal differentiation of B-1 cells.
Required for normal B cell differentiation and proliferation in response to antigen challenges .
Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
宿主种属
大鼠(Rat)
特异性
CD19
种属反应性
小鼠(Mouse)
免疫原
Transfected K562 cells expressing the extracellular domain of murine CD19.
阳性对照
Flow: C57BL/6 Mouse splenocytes
偶联
Unconjugated
备注
此产品可替代 Ab094090
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein G purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
10mM PBS, pH 7.2-7.4
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Flow Cytometry analysis of C57BL/6 Mouse splenocytes labelling CD19 with Recombinant CD19 Antibody (Ab222893) (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Ab141774) (left panel) and detected with AF 647 - conjugated affinipure goat anti-Rat IgG.
Flow Cytometry analysis of C57BL/6 Mouse splenocytes labelling CD19 (red) with Recombinant CD19 Antibody (Ab222893) at 0.2 μg/mL for 1 hour at 4°C and detected with AF 647 - conjugated affinipure goat anti-Rat IgG. Blue - Rat IgG Isotype Control Antibody (Ab141774). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD19 Antibody (Ab222893) - SEC
The purity of Recombinant CD19 Antibody (Ab222893) is more than 95% verified by HPLC.
ZJ26F0232259
危险品化学品经营许可证（带存储）