Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance.
Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis.
Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL.
Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (By similarity).
Modulates B-cell biology through ERK1/2 activation in a Ca2+-dependent pathway via the non-selective Ca2+ channel TRPC1, leading to IL-10 production (By similarity).
宿主种属
大鼠(Rat)
特异性
Mouse CD5
种属反应性
小鼠(Mouse)
免疫原
Mouse Thymus / Spleen
阳性对照
Flow Cytometry: C57BL/6 mouse splenocytes
偶联
Unconjugated
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 7.4
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant CD5 Antibody (Ab222902) - Flow Cytometry Flow Cytometry analysis of C57BL/6 Mouse splenocytes labelling CD5 with Recombinant CD5 Antibody (Ab222902) (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Ab141774) (left panel) and detected with AF 647 - conjugated affinipure goat anti-Rat IgG.
Recombinant CD5 Antibody (Ab222902) - Flow Cytometry Flow Cytometry analysis of C57BL/6 Mouse splenocytes labelling CD5 (red) with Recombinant CD5 Antibody (Ab222902) at 0.2 μg/mL for 1 hour at 4°C and detected with AF 647 - conjugated affinipure goat anti-Rat IgG. Blue - Rat IgG Isotype Control Antibody (Ab141774). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD5 Antibody (Ab222902) - SEC The purity of Recombinant CD5 Antibody (Ab222902) is more than 95% verified by HPLC.
ZJ25F0926969
危险品化学品经营许可证（带存储）