Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity).
Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity.
宿主种属
小鼠(Mouse)
特异性
Mouse CD45
种属反应性
小鼠(Mouse)
免疫原
B10.S mouse thymocytes and splenocytes
阳性对照
Flow Cytometry: C57BL/6 mouse splenocytes
偶联
Unconjugated
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 6.0
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.
图片
Recombinant CD45.2 Antibody (Ab222921) - Flow Cytometry Flow Cytometry analysis of C57BL/6 Mouse splenocytes labelling CD45.2 with Recombinant CD45.2 Antibody (Ab222921) conjugated with biotin (right panel) at 1.0 μg/mL for 1 hour at 4°C, compared with Mouse IgG Isotype Control Antibody (Biotin) (Ab180306) (left panel) and detected with SA-PE (rp156150).
Recombinant CD45.2 Antibody (Ab222921) - Flow Cytometry Flow Cytometry analysis of C57BL/6 Mouse splenocytes labelling CD45.2 (red) with Recombinant CD45.2 Antibody (Ab222921) conjugated with biotin at 1.0 μg/mL for 1 hour at 4°C and detected with SA-PE (rp156150). Blue - Mouse IgG Isotype Control Antibody (Biotin) (Ab180306). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD45.2 Antibody (Ab222921) - SEC The purity of Recombinant CD45.2 Antibody (Ab222921) is more than 95% verified by HPLC.
ZJ25F0825748
危险品化学品经营许可证（带存储）