Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
宿主种属
小鼠(Mouse)
特异性
Human CD34
种属反应性
人(Human)
免疫原
Permanent human cell line from a patient with myeloid leukaemia.
Flow Cytometry analysis of KG-1α cells labelling CD34 (red) with Recombinant CD34 Mouse mAb (Ab330978) at 0.2 μg/mL for 1 hour at 4°C. AffiniPure Goat anti-Mouse IgG, Fcγ fragment specific (AF647) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.