BR-cpd7 is a PROTAC degrader for fibroblast growth factor receptor FGFR1/2 with DC 50 of 10 nM. BR-cpd7 arrests cell cycle, inhibits proliferations of FGFR1/2 aberrant activated tumor cells. (Pink: ligand for target protein FGFR-IN-12 ; Black: linker; Blue: ligand for E3 ligase Thalidomide-NH-CH2-COOH )