计算溶液所需的质量、体积或浓度。
概述
BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC 50 of 59.1 nM for human TLR7 . BBIQ is a powerful vaccine adjuvant that enhances innate immune responses
In Vitro
BBIQ induces IFN-α in human PBMCs (520 pg/mL at 5 µg/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In mice treated with Chloroquine (CQ) alone, parasite ( P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Whereas, mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ + CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy. Serum levels of IFN-γ and IL-12 are higher on same day in mice treated with BBIQ + CQ which reveals the generation of strong Th1 immune response in mice against the infection . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:TLR7 59.1 nM (EC 50 , Human TLR7)
规格
规格或纯度
≥97%
英文名称
BBIQ
生化机理
BBIQ 是一种咪唑喹啉化合物，是一种强效的选择性收费样受体 7（TLR7）激动剂，对人类 TLR7 的 EC 50 值为 u202f59.1u202fnM 。BBIQ 是一种强大的疫苗佐剂，可增强先天性免疫反应。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激动剂
纯度
≥97%
名称和识别符
分子类型
小分子
分子量
330.43
高级数据
化学和物理性质
溶解性
DMSO : 16.67 mg/mL (50.45 mM; ultrasonic and warming and heat to 60°C)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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技术文档和文章
溶液计算器
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危险品化学品经营许可证（带存储）