计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥97% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC 50 of 59.1 nM for human TLR7 . BBIQ is a powerful vaccine adjuvant that enhances innate immune responses
In Vitro
BBIQ induces IFN-α in human PBMCs (520 pg/mL at 5 µg/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In mice treated with Chloroquine (CQ) alone, parasite ( P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Whereas, mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ + CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy. Serum levels of IFN-γ and IL-12 are higher on same day in mice treated with BBIQ + CQ which reveals the generation of strong Th1 immune response in mice against the infection . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:TLR7 59.1 nM (EC 50 , Human TLR7)
规格
规格或纯度
≥97%
英文名称
BBIQ
生化机理
BBIQ 是一种咪唑喹啉化合物，是一种强效的选择性收费样受体 7（TLR7）激动剂，对人类 TLR7 的 EC 50 值为 u202f59.1u202fnM 。BBIQ 是一种强大的疫苗佐剂，可增强先天性免疫反应。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激动剂
纯度
≥97%
名称和识别符
分子类型
小分子
分子量
330.43
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 16.67 mg/mL (50.45 mM; ultrasonic and warming and heat to 60°C)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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