计算溶液所需的质量、体积或浓度。
概述
B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC 50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity
In Vitro
B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E. B-Raf IN 10 shows an IC 50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E. B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
Form:Solid
IC50& Target:BRAF-V600E < 50 nM (IC 50 ) Braf 50-100 nM (IC 50 )
规格
规格或纯度
≥99%
英文名称
B-Raf IN 10
生化机理
B-Raf IN 10（化合物 C09）是一种 BRAF 抑制剂，其 IC 50 在 50 到 100 nM 之间。B-Raf IN 10 具有抗肿瘤活性。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
494.49
高级数据
化学和物理性质
溶解性
DMSO : 100 mg/mL (202.23 mM; ultrasonic and warming and heat to 60°C)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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