计算溶液所需的质量、体积或浓度。
概述
BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD)
In Vivo
BSc3094 (3 mg/kg; i.v.) direct intraventricular administration reduces sarkosyl-insoluble Tau . BSc3094 (0.075~1.5 mM; intraventricular administration) reduces the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70% . BSc3094 reverses the pre-synaptic impairment in organotypic hippocampal slices from pro-aggregant mice, by reversing the pairedpulse depression observed in non-treated pro-aggregant Tau slices after applying a paired-pulse stimulus of the Schaffer collaterals. BSc3094 reverses the increase in Tau phosphorylation levels in rTg4510 mice down to control level. BSc3094 partially reversed the memory deficits in rTg4510 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice Dosage: 3 mg/kg Administration: I.v. Result: Direct intraventricular administration reduced sarkosyl-insoluble Tau. Animal Model: rTg4510 mice Dosage: 0.075~1.5 mM Administration: Intraventricular administration Result: Reduced the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%.
Form:Solid
IC50& Target:Tau aggregation
规格
规格或纯度
≥98%
英文名称
BSc3094
生化机理
BSc3094 是一种 Tau 聚集抑制剂。BSc3094 可用于阿尔茨海默病（AD）的研究。
储存条件
避光,-80℃储存
运输条件
特低温运输
纯度
≥98%
名称和识别符
分子类型
小分子
Smiles
O=C(C1=CC=C2N=CNC2=C1)NNC3=NC(C4=CC=C([N+]([O-])=O)C=C4)=CS3
分子量
380.38
高级数据
化学和物理性质
溶解性
DMSO : 33.33 mg/mL (87.62 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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