计算溶液所需的质量、体积或浓度。
概述
BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor
In Vivo
Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MRL/lpr mice . Dosage: 1 mg/kg. Administration: Subcutaneous injection daily from 8 to 14 weeks of age. Result: Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.
Form:Solid
IC50& Target:PAD
规格
别名
BB-Cl-脒盐酸盐
规格或纯度
≥99%
英文名称
BB-Cl-Amidine hydrochloride
生化机理
BB-Cl-Amidine 盐酸盐是一种肽基精氨酸脱氨酶（PAD）抑制剂。
储存条件
2-8°C储存,干燥
运输条件
低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
496.43
高级数据
化学和物理性质
溶解性
DMSO : ≥ 100 mg/mL (201.44 mM) H2O : 1.3 mg/mL (2.62 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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危险品化学品经营许可证（带存储）