计算溶液所需的质量、体积或浓度。
B022
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor ( K i of 4.2 nM; IC 50 =15.1 nM). B022 protects liver from toxin-induced inflammation, oxidative stress, and injury
In Vitro
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner. B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5. B022 prevents NIK- or H2O2-induced β cell death and also ameliorates streptozotocin (STZ)-induced β cell death and hyperglycemia. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Hepa1 cells Concentration: 0 μM, 0.5 μM, 5 μM Incubation Time: 12 hours Result: Suppressed NIK-induced p52 formation in a dose-dependent manner. RT-PCRCell Line: Hepa1 cells Concentration: 0 μM, 0.5 μM, 5 μM Incubation Time: 12 hours Result: Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.
In Vivo
B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: STOP-NIK male mice (8 weeks) infected with Ad-cre Dosage: 30 mg/kg Administration: Intravenous injection; twice a day; for 10 days Result: Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK.
IC50& Target:Ki: 4.2 nM (NF-κB-inducing kinase (NIK))
规格
规格或纯度
Moligand™, 10mM in DMSO
英文名称
B022
生化机理
B022 是一种强效的选择性 NF-κB 诱导激酶（NIK）抑制剂（K i 为 4.2 nM；IC 50 =15.1 nM）。B022 可保护肝脏免受毒素引起的炎症、氧化应激和损伤。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
分子量
397.88
技术文档
高级数据
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技术文档和文章
溶液计算器
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