计算溶液所需的质量、体积或浓度。
概述
Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride s
Appearance:Solid
IC50& Target:KDM1/LSD1
In Vitro:Bomedemstat dihydrochloride selectively inhibits proliferation and induces apoptosis of Jak2 V617F cells by concomitantly increasing expression and methylation of p53. Bomedemstat (50 nM-1 μM; 96 h; SET-2 cells) dihydrochloride enhances survival, ind
In Vivo:Bomedemstat (oral gavage; 45mg/kg; once daily; 56 d) dihydrochloride normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis. MCE has not independently confirmed the ac
Biological Activity:Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride s
规格
别名
盐酸波美司他
规格或纯度
≥99%
英文名称
Bomedemstat dihydrochloride
储存条件
-20°C储存,干燥
运输条件
超低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
592.54
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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危险品化学品经营许可证（带存储）