Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.
In vitro

Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the binding (kon) and by increasing the unbinding (koff) rates of GABAARs. Chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way, leading to a block at positive potentials and an increased open probability at negative potentials.

In vivo

Chlorpromazine independently down-regulates the production of various T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and up-regulates the secretion of IL-10 in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine -mediated amplification of the SEB-driven Chlorpromazine secretion is accompanied by an enhanced IL-10 mRNA accumulation. Chlorpromazine protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and inhibits TNF serum levels. Chlorpromazine protects against LPS lethality when administered 30 minutes (min) before, simultaneously, or up to 10 min after LPS and is ineffective when given 30 min after LPS, paralleling the inhibitory effect on TNF production. Chlorpromazine significantly inhibits LPS lethality and hepatotoxicity in mice sensitized to LPS toxicity by actinomycin D, whereas under these conditions DEX is inactive. Chlorpromazine protects brain tissue from hypoxia-induced irreversible loss of synaptic transmission in rats. Chlorpromazine also significantly delays the occurrence of the hypoxia-induced spreading depression (SD) in rats.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

Sonazine

规格或纯度

10mM in DMSO

英文名称

Chlorpromazine HCl（CPZ）

生化机理

盐酸氯丙嗪（Sonazine）是一种多巴胺和钾通道抑制剂，对内向纠正型 K+ 电流和时间依赖型外向电流的 IC50 分别为 6.1 和 16 μM。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

拮抗剂

作用机制

D2 类多巴胺受体拮抗剂

名称和识别符

EC号

200-701-3

分子类型

小分子

Isomeric SMILES

CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl

关联CAS

50-53-3

PubChem CID

6240

UN Number

2811

Packing Group

分子量

355.33

Beilstein号

3779989

Reaxy-Rn

3779989

高级数据

关联靶点（人）

CYP2D6 Tclin 细胞色素 P450 2D6(Cytochrome P450 2D6) (1 活性数据)

点击查看靶蛋白信息： CYP2D6

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

DRD2 Tclin D（2）多巴胺受体(D(2) dopamine receptor) (1 活性数据)

点击查看靶蛋白信息： DRD2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

溶解性

Solubility (25°C) In vitro DMSO: 35 mg/mL (196.47 mM); Water: 35 mg/mL (196.47 mM); Ethanol: Insoluble;

熔点

196°C

安全和危险性（GHS）

象形图

GHS02, GHS06

信号词

危险

危险声明

H227: 可燃液体

H301: 吞咽会中毒

H330: 吸入致命

预防措施声明

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P271: 仅在室外或通风良好的地方使用。

P284: 如果通风不良，请佩戴呼吸防护装置。

P320: 迫切需要特殊治疗（请参阅此标签上的...）。

P321: 特殊处理（请参阅此标签上的...）。

P330: 漱口

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器送到批准的废物处理厂处理

P301+P316: 如果吞咽：立即寻求紧急医疗救助。

P316: 立即寻求紧急医疗救助。

WGK Germany

RTECS

SO1750000

Class

6.1

Merck Index

2185

个人防护装备

Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

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目录：技术文章

探索主题:

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Furin: A Review of Its Structural Features, Substrate Recognition, and Research Applications

目录：技术文章

探索主题:

Furin PCSK3 Proprotein convertase Trans-Golgi network Multibasic cleavage site Protein maturation Host protein processing