计算溶液所需的质量、体积或浓度。
概述
Information
C75 trans C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid sy
In vitro
C75 is toxic to prostate cancer cells. C75 reduces cell migration, while enhances radiation-induced clonogenic kill and enhances the spheroid growth delay induced by radiation exposure. Apoptosis induction by radiation exposure is enhanced by C75 treatment. C75 inhibits fatty acid synthesis and growth of established cancer cell lines from neu-N transgenic mice. C75 reduces the proliferation and expression of FAS, neu, and related genes in mammary epithelium.
In vivo
C75 inhibits fatty acid synthesis and in vivo mammary cancer development. C75 treatment prevents mammary cancer development and retards mammary development in neu-N transgenic mice.
Cell Data
cell lines：Glioma cell lines, BMDM, CRL-2467, HUVEC and HBMEC cell lines
Concentrations：5 μM, 25 μM, 35 μM, 50 μM
Incubation Time：3 h, 6 h, 24 h
Powder Purity:≥98%
规格
英文别名
trans-C75, (±)-C75
规格或纯度
10mM in DMSO
英文名称
C75 trans
生化机理
C75 trans（trans-C75，(±)-C75）是一种新型、强效的脂肪酸合成酶（FAS/FASN）合成抑制剂，在克隆生成试验和球状生长试验中的 IC50 分别为 35 μM 和 50 μM。C75 是研究代谢紊乱和癌症中脂肪酸合成的一种工具。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
Isomeric SMILES
CCCCCCCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O
分子量
254.33
Reaxy-Rn
9925444
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9925444&ln=
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
Why Do Cancer Cells Synthesize Their Own Fatty Acids? From the De Novo Fatty Acid Synthesis Pathway to Experimental Assessment
目录： 技术文章
溶液计算器
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危险品化学品经营许可证（带存储）