计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133 , OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila.
In Vitro
CP681301 (1 µM; 96 h) shows variably cytotoxic to the tested GSC cultures but is not toxic to NHNPs. CP681301 (0, 10, 50 µM; 48 h) decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs. CP681301 (0, 0.5, 1 µM; ) suppresses the expression of CREB Ser133 phosphorylation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: NHNP, N12.159, GBM121, GBM39, N08-74 cells Concentration: 1 µM Incubation Time: 96 h Result: Showed variably cytotoxic to the tested GSC cultures but was not toxic to NHNPs (normal human neuro-progenitors). Western Blot AnalysisCell Line: GBM 121, GBM39 cells Concentration: 1 µM Incubation Time: 48 h Result: Suppressed the expression of CD133, OLIG2, and SOX2 and cell proliferation marker KI67.
In Vivo
CP681301 (1 mM; fed; 10 days) shows anti-tumor activity in 0- to 2-day-old adult Drosophila . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 0- to 2-day-old adult Drosophila (brat-RNAi tumors) Dosage: 1 mM Administration: Fed, 10 days Result: Reduced active phospho-dCdk5 (Y15) in tumor cells and the self-renewal properties of stem cells, increased the expression of neuronal marker ElaV in these cells and increased the median survival by 2.8-fold.
Form:Solid
规格
规格或纯度
≥99%
英文名称
CP681301
生化机理
CP681301 是一种强效 CDK5 抑制剂。CP681301 具有抗增殖活性。CP681301 可降低胶质瘤干细胞（GSCs）中 CD133、OLIG2、SOX2、KI67 和 pCDK5 蛋白水平的表达。CP681301 可减少小鼠胶质瘤异种移植的自我更新。CP68
储存条件
避光,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
298.38
技术文档
高级数据
化学和物理性质
溶解性
DMSO : ≥ 100 mg/mL (335.14 mM)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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