计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes.
In Vitro
Cadisegliatin (TTP-399) increases glucose metabolism in rat hepatocytes, the EC 50 values of lactate and glycogen in 15 nM glucose are 2.39 μM and 2.64 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
TTP399 (200 mg/kg, per os, p.o.) has no effect on plasma glucose and insulin in fasted rats. TTP399 (75 or 150 mg/kg, per day, for 4 weeks) improves glucose homeostasis in ob/ob mouse model. TTP399 (50 mg/kg, per day, for 13 weeks) is effective in reducing plasma glucose during an oral glucose tolerance test (OGTT) in minipigs model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nondiabetic fasted ratsDosage: 200 mg/kg Administration: 200 mg/kg, per os (p.o.) Result: Did not change the insulin and glucose concentrations in plasma. Animal Model: ob/ob mouse modelDosage: 75 or 150 mg/kg Administration: 75 or 150 mg/kg, per day, for 4 weeks Result: Reduced the expression of HbA1c, blood glucose concentrations, lactate concentrations and liver glycogen depots. Improved the lipid profile, reduced plasma, liver TG concentrations and the weight gain at the highest dose. Animal Model: Gottingen minipigsDosage: 50 mg/kg Administration: 50 mg/kg, per day, for 13 weeks Result: Eliminated the blood glucose excursion in Minipigs.
Form:Solid
规格
别名
钙调素
规格或纯度
≥99%
英文名称
Cadisegliatin
生化机理
Cadisegliatin（TTP-399）是一种潜在的口服活性肝脏选择性葡萄糖激酶（GK）激活剂。Cadisegliatin 具有抗高血糖活性。Cadisegliatin 可用于 2 型糖尿病的研究。
储存条件
避光,-80℃储存
运输条件
特低温运输
作用类型
激活剂
纯度
≥99%
名称和识别符
分子类型
小分子
Isomeric SMILES
CCCOC1CCC(CC1)N(C2CCCCC2)C(=O)NC3=NC=C(S3)SCC(=O)O
PubChem CID
分子量
455.63
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 125 mg/mL (274.35 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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