CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis.
In Vitro
CFTR corrector 8 (compound 12) shows EC 50 s of 1 μM (CSE-HRP assay) and 3 μM (HBE-TECC assay). CFTR corrector 8 exhibits hepatocyte clearance rate of 1250/775 L/hr/kg (human/rat). MCE has not independently confirmed the accuracy of these methods. They are for reference only.