计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥97% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,充氩,干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3 , can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors
In Vitro
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM; 24 h) down-regulates the transcription factors Oct 4, Sox 2 and Nanog of mESCs. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM) inhibits integrin gene expression mESC-col I (type I collagen) constructs. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM)-treated mESC leads to the formation of aggregates and detachment from the surface. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: MESCs Concentration: 0.5 mM Incubation Time: 24 h Result: Down-regulated Oct 4, Nanog, Sox 2 by 99%, 97.5%, and 90% respectively. Up-regulated Rex1 gene expression.
In Vivo
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM, 24 h)-treated mESCs in the presence/absence of Leukemia inhibitory factor (LIF) (injected in both thighs) generated teratomas in severe combined immunodeficiency (SCID) mice, which indicates that the process of mESC tumor formation in vivo is dependent on integrin interaction . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:αvβ3
规格
别名
环(精氨酸-甘氨酸-天冬氨酸-D-苯丙氨酸-半胱氨酸)
规格或纯度
≥97%
英文名称
Cyclo(Arg-Gly-Asp-D-Phe-Cys)
生化机理
环（Arg-Gly-Asp-D-Phe-Cys）（Cyclo RGDfC）是一种环状 RGD 肽，与 αvβ3 具有高亲和力，能破坏细胞整合素的相互作用。Cyclo（Arg-Gly-Asp-D-Phe-Cys）可抑制胚胎干细胞（ESC）中多能标志物的表达，并抑制肿瘤细胞的生长。
储存条件
避光,充氩,干燥,-80℃储存
运输条件
特低温运输
纯度
≥97%
产品线
生物产品
名称和识别符
分子类型
肽
IUPAC Name
2-[5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-8-(sulfanylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
INCHI
1S/C24H34N8O7S/c25-24(26)27-8-4-7-14-20(36)28-11-18(33)29-16(10-19(34)35)22(38)31-15(9-13-5-2-1-3-6-13)21(37)32-17(12-40)23(39)30-14/h1-3,5-6,14-17,40H,4,7-12H2,(H,28,36)(H,29,33)(H,30,39)(H,31,38)(H,32,37)(H,34,35)(H4,25,26,27)
InChi Key
WNYJVAMZRBTOPE-UHFFFAOYSA-N
Smiles
C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CS)CC2=CC=CC=C2)CC(=O)O
Isomeric SMILES
C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CS)CC2=CC=CC=C2)CC(=O)O
PubChem CID
MeSH Entry Terms
c(RGDfC);cyclo(Arg-Gly-Asp-Phe-Cys);cyclo(arginyl-glycyl-aspartyl-phenylalanyl-cysteinyl);cyclo(RGDfC);cyclo-(Arg-Gly-Asp-D-Phe-Cys)
分子量
578.64
技术文档
高级数据
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : 50 mg/mL (86.41 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
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