计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I , ROCK II with IC 50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR)
In Vitro
CAY10746 (compound 12j) has inhibitory activity for ROCK I, ROCK II with IC 50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 (0.1, 1 and 10 μM; 0.25, 1, 2 and 4 h) inhibits ROCK kinase activity in SH-SY5Y cells. CAY10746 (1 μM; 24 h, 36 h) inhibits endothelial cell migration in vitro. CAY10746 (1 μM; 5 days) protects retinal neurons from high glucose-induced oxidative stress and apoptosis-mediated cell death. CAY10746 (1 μM; 5 days) suppresses the improper proliferation of Müller cells and promoted the regression of vascular vessels in retinal explants cultured in a high glucose microenvironment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: SH-SY5Y cells Concentration: 0.1, 1 and 10 μM; 10 μM Incubation Time: 2 h; 0.25, 1, 2 and 4 h Result: Inhibited the phosphorylation of MYPT1 but did not impact the MYPT1 expression in dose-dependence and time- dependence. Cell Proliferation AssayCell Line: SH-SY5Y cells Concentration: 1 μM Incubation Time: 5 days Result: Significantly protected the cells from death. Cell Migration AssayCell Line: HUVEC cells Concentration: 1 μM Incubation Time: 24 h, 36 h Result: Significantly reduced migrating cell numbers and significantly reduce the rate of wound healing at 24 h and 36 h. Apoptosis AnalysisCell Line: ex vivo DR model Concentration: 1 μM Incubation Time: 5 days Result: Significantly protected neuronal cells from death.
Form:Solid
IC50& Target:IC50: 0.014 μM (ROCK I),0.003 μM (ROCK II)
规格
规格或纯度
≥99%
英文名称
CAY10746
生化机理
CAY10746 是一种选择性 Rho 激酶（ROCK）抑制剂。CAY10746 对 ROCK I 和 ROCK II 具有抑制活性，IC 50 值分别为 0.014 μM 和 0.003 μM。CAY10746 可用于糖尿病视网膜病变（DR）的研究。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
457.48
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 83.33 mg/mL (182.15 mM; ultrasonic and warming and heat to 60°C)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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