计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.
In Vitro
Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils. Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau. Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elav c155 -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control. Dosage: 0.75 mg/mL. Administration: Dripped every other day. Result: Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).
规格
别名
氯胺酮
规格或纯度
10mM in DMSO
英文名称
Cl-NQTrp
生化机理
Cl-NQTrp 能显著破坏 Tau 衍生的 PHF6 (VQIVYK) 肽和全长 tau 蛋白预先形成的柱状聚集体。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
分子量
394.81
技术文档
高级数据
化学和物理性质
密度
1.1
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溶液计算器
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