H2229286计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
D-赤型-鞘氨醇-1-磷酸酯(C20碱), S1P 2 受体激动剂
有货
概述
product description：
Sphingosine-1-phosphate (S1P) is a zwitterionic sphingolipid. It is found in insects, yeasts and plants. Sphingosine-1-Phosphate (d20:1) is a phosphorylated derivative of long chain base C20 sphingosine.
application：
Sphingosine-1-phosphate (S1P)-d7 has been used as a reference standard in liquid chromatography/tandem mass spectrometry analysis for quantitative analyses of S1P d20:1 in central nervous system of healthy mice and in human glioblastoma tissue.
Biochemical mechanism:
Sphingosine-1-phosphate (S1P) is an important cellular metabolite and signaling lipid in animal cells. It aids in various physiological and cellular processes such as atherosclerosis, inflammation, immunity, tumorigenesis, and cell proliferation. S1P plays a vital role in mammalian brain and cardiac development. S1P d20:1 serves as a partial agonist at the S1P receptor 2 (S1P2). It has an ability to inhibit S1P d18:1‐mediated cyclooxygenase 2(COX2) induction.
规格
英文别名
(2S,3R,4E)-2-Azaniumyl-3-hydroxyicos-4-en-1-yl hydrogen phosphate | [(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate | Sphingosine-1-Phosphate (d20:1), D-erythro-sphingosine-1-phosphate (C20 base), powder | D-erythro-Sphingosine-C20-1-phosphate | Sphingosine-1-Phosphate (d20:1) | S1P (d20:1) | S1P d20:1
规格或纯度
Moligand™, ≥99%
英文名称
D-erythro-sphingosine-1-phosphate (C20 base)
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激动剂
作用机制
S1P 2 受体激动剂
纯度
≥99%
名称和识别符
分子类型
小分子
IUPAC Name
[(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate
INCHI
1S/C20H42NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)19(21)18-26-27(23,24)25/h16-17,19-20,22H,2-15,18,21H2,1H3,(H2,23,24,25)/b17-16+/t19-,20+/m0/s1
InChi Key
YUUWWSOTAGQJFW-YIVRLKKSSA-N
Smiles
CCCCCCCCCCCCCCCC=CC(C(COP(=O)(O)[O-])[NH3+])O
Isomeric SMILES
CCCCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)[O-])[NH3+])O
分子量
407.52
Reaxy-Rn
35857216
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35857216&ln=
高级数据
三维结构
交互式化学结构模型
关联靶点（人）
S1PR2
Tchem
鞘氨醇 1-磷酸受体 2(Sphingosine 1-phosphate receptor 2)
(0 活性数据)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
溶液计算器
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