DCN1-IN-2 是一种 DCN1 抑制剂,IC50 值为 2.96 nM。DCN1-IN-2 可以缓解 Ang II/TGFβ 诱导的心脏成纤维细胞活化。DCN1-IN-2 可以通过选择性抑制 cullin 3 来减少 ISO 诱导的小鼠心脏纤维化和重塑。
DCN1-IN-2 is a DCN1 inhibitor with an IC 50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ -induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3.