葡聚糖酶水解右旋糖酐上的(1,6)-α-D-葡萄糖苷键。
本产品是通过毛壳菌(Chaetomium erraticum)的深层发酵产生的一种真菌葡聚糖酶。
它具有许多工业和临床应用,例如食品加工、糖修饰和药物制备。葡聚糖酶广泛用于生产交替甜菜和异麦芽寡糖(IMO),这是一种益生功能食品。从葡聚糖酶获得的低分子量葡聚糖可用作合成血容量扩充剂。葡聚糖酶可与抗体偶联以检测肿瘤细胞。它通过使牙齿中的微生物葡聚糖沉积物解聚来防止牙菌斑的发生。因此,它被用于牙科护理产品。
在pH 3-7范围内以及最高约70 °C的温度下稳定。对于绝大多数应用,比较适合的条件是pH 5-6且 50-60 °C的温度。
来自毛壳菌的葡聚糖酶已被用于:
微载体溶解以产生药物发现用多细胞 3D 球体;
细菌分离物中细胞外多糖(EPS)的体外消化;
葡聚糖酶固定化的研究;
研究交替糖酶促修饰工艺条件的优化。
转基因状态
本产品不是转基因生物。
酶制剂产品是通过微生物发酵制作而成,但微生物不会存留在最终产品中。用于生产的微生物没有采用现代生物技术对其进行改良。
储存条件
贮存温度: 2-8℃。
储存时必须保持包装完好,储存在干燥的环境中,并避免阳光直射。 请按照使用建议使用,并在最佳使用期限到期日之前使用本产品,以避免增加使用剂量。
安全与使用注意事项
酶是一种蛋白质。吸入粉尘或气溶胶可能致敏,并可能导致致敏个体产生过敏反应。有些酶在长时间接触后会刺激皮肤、眼睛和粘膜。
Dextranase hydrolyzes the (1,6)-alpha-D-glucosidic linkages in dextran.
This product is a fungal dextranase produced by submerged fermentation of Chaetomium erraticum.
It has many industrial and clinical applications such as food processing, sugar modification, and medicine preparation. Dextranase is widely used to produce alternated sugar beet and isomaltooligosaccharides (IMOs), a prebiotic functional food. The low molecular weight dextran obtained from dextranase serves as a synthetic blood volume expander. Dextranase can be coupled to antibodies for the detection of tumor cells. It prevents the occurrence of dental plaques by depolymerizing microbial dextran deposits in teeth. Hence, it is used in dental care products.
Stable in the pH range of 3-7 and at temperatures up to approx. 70 °C. For most applications, the preferred conditions are pH 5-6 and a temperature of 50-60 °C.
Application
Dextranase from Chaetomium erraticum has been used:
in microcarrier dissolution to produce multicellular 3D spheroids for drug discovery,
in in vitro digestion of extracellular polysaccharide (EPS) from the bacterial isolates,
in a study to investigate the immobilization of dextranase,
to investigate the optimization of process conditions for enzymatic modification of alternan.
Genetic Modification Status
This product is not a genetically modified organism (GMO).
Enzyme preparations are produced by microbial fermentation, with no residual microorganisms in the final product. The microorganisms used for production have not been modified by modern biotechnology.
Storage Conditions
Storage temperature: 2–8℃.
The original packaging must be kept intact during storage. Store in a dry environment and avoid direct sunlight.
Use the product in accordance with the recommended usage and prior to the expiration date of the shelf life to avoid the need for increased dosage.
Safety and Handling Precautions
Enzymes are proteins. Inhalation of dust or aerosols may cause sensitization and trigger allergic reactions in sensitized individuals.
Prolonged contact with some enzymes may cause irritation to the skin, eyes and mucous membranes.