A2604884计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
Moligand™ 级 提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光,充氩。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng , and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.
In Vitro
Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay
Cells are cultured in 6-well plates with glucose (LG) or high glucose control (HG) and then treated with valsartan (1.0 × 10 -3 M) or Dencichin (1.0 × 10 -5 M, 1.0 × 10 -4 M and 1.0 × 10 -3 M) for 24 h before analysing the activation of FN, Col I, and Col IV expression by ELISA and analysing MMP-9 and TIMP-1 expression by immunofluorescence. Each experiment is repeated at least three times throughout the study. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal administration
Male SD rats weighted approximately 200 ± 20 g (eight weeks old) are kept at 23 ± 2°C. The rats are randomLy allotted into two groups: normal group (n = 16) and diabetic nephropathy (DN) group (n = 60). The normal rats fed with normal diet and vehicle fall into the normal control group (NC, n = 8) and the normal rats fed with normal diet and Dencichin fall into the Dencichin control group (De C, n = 8). The rats in the diabetic group are fed the high-sugar-high-fat diet (composition: Common breeding material 54.6%, lard oil 16.9%, sucrose 14%, casein 10.2%, gunk 2.1%, maltodextrin 2.2%). Five weeks later, DN is induced by administering of 40 mg/kg STZ though intraperitoneal injection, and the normal rats are treated with vehiclecitrate buffer (0.1 M, pH 4.2). Next, the DN rats (n = 32) are assigned into four groups and oral administered with metformin hydrochloride (a positive control) at 80 mg/kg/day, (DN+Met, n = 8), which is dissolve into distilled water to make a 2 mg/mL solution before use; vehicle control for the DN control group (DN, n = 8), or Dencichin. The Dencichin group is divided into a high Dencichin group ( 160 mg/kg/day ; DN+De H, n = 8) and a low Dencichin group ( 80 mg/kg/day ; DN+De L, n = 8), which are dissolved into distilled water to make a 5 mg/mL and 2.5 mg/mL solution before use and oral administered at the dosage once per day. Blood glucose is measured each month. 8 w after administering with Dencichin, the rats are killed . aladdin has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:PHD-2
规格
别名
(S)-2-氨基-3-(羧甲酰胺基)丙酸 | 3-[(羧基羰基)氨基]-L-丙氨酸 | β-N-草酰基-L-α | β-二氨基丙酸 | β-二氨基丙酸酯 | Nβ-草酰基-L-丙氨酸 | 田七氨酸
英文别名
N3-Oxalyl-L-2,3-diaminopropanoate | A13552 | 3-N-Oxalyl-L-2,3-diaminopropanoic acid | Dencichin | UNII-O8VT5BZ48B | beta-ODAP | N-Oxalyl-L-alpha-beta-diaminopropionic acid (BOAA,ODAP) | oxalyldiaminopropionic acid, (L-Ala)-isomer | beta-N-Oxalyl-L-alpha,b
规格或纯度
Moligand™, ≥98%
英文名称
Dencichine
生化机理
Dencichin 最初是从三七中提取的一种非蛋白氨基酸，可抑制 HIF-脯氨酰羟化酶-2（PHD-2）的活性。
储存条件
2-8°C储存,避光,充氩
运输条件
低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
PubChem SID
分子类型
小分子
IUPAC Name
(2S)-2-amino-3-(oxaloamino)propanoic acid
INCHI
1S/C5H8N2O5/c6-2(4(9)10)1-7-3(8)5(11)12/h2H,1,6H2,(H,7,8)(H,9,10)(H,11,12)/t2-/m0/s1
InChi Key
NEEQFPMRODQIKX-REOHCLBHSA-N
Smiles
C(C(C(=O)O)N)NC(=O)C(=O)O
Isomeric SMILES
C([C@@H](C(=O)O)N)NC(=O)C(=O)O
关联CAS
PubChem CID
MeSH Entry Terms
(2-amino-2-carboxymethyl)-L-oxamic acid;2-oxalylamino-3-aminopropionic acid;3-amino-N-(carboxycarbonyl)-DL-alanine;3-amino-N-(carboxycarbonyl)alanine;3-oxalylamino-2-aminopropionic acid;beta-N-oxalylamino-L-alanine;beta-N-oxalylaminoalanine;beta-N-oxalyla
分子量
176.13
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机酸及其衍生物 |
| 类（Class) | 羧酸及其衍生物 |
| 亚类（Subclass） | 氨基酸、肽和类似物 |
| 中间层级节点（Intermediate Tree Nodes） | 氨基酸及其衍生物 - α氨基酸及其衍生物 - α氨基酸 |
| 直接上位类(Direct Parent) | L-α氨基酸 |
| 其他上位类（Alternative Parents） | 二羧酸及其衍生物 仲羧酸酰胺 氨基酸 羧酸 有机光子化合物 有机氧化物 单烷基胺 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 脂肪族非环化合物 - 氨基酸 - 氨基酸 - 羰基 - 羧酰胺基 - 羧酰胺基 - 二羧酸或其衍生物 - 烃衍生物 - L-α-氨基酸 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 初级脂肪胺 - 初级胺 - 醛基 |
| 描述（Description） | 该化合物属于有机化合物中的L-α-氨基酸类。这类α-氨基酸的α-碳原子具有L型构型。 |
| 外部描述符（External Descriptors） | N(beta)-acyl-L-2,3-diaminopropionic acid |
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : 5 mg/mL (28.39 mM; Need ultrasonic) H2O : 5 mg/mL (28.39 mM; Need ultrasonic)
敏感性
对光线敏感；对空气敏感
分子量
176.130 g/mol
XLogP3
-4.100
氢键供体数Hydrogen Bond Donor Count
4
氢键受体数Hydrogen Bond Acceptor Count
6
可旋转键计数Rotatable Bond Count
4
精确质量Exact Mass
176.043 Da
单同位素质量Monoisotopic Mass
176.043 Da
拓扑极表面积Topological Polar Surface Area
130.000 Ų
重原子数Heavy Atom Count
12
形式电荷Formal Charge
0
复杂度Complexity
214.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
1
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
此产品的引用文献
溶液计算器
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