计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD).
In Vitro
DDO-7263 (20 μM; 2-24 h) can upregulate the protein levels of HO-1 and NQO1 in concentration-dependent manners. DDO-7263 (2.5, 5, 10, 20, 40, 80 μM; 24 h) can upregulate the survival rate of PC12 and THP-Ms cell after 400 μM H 2 O 2 in a concentration-dependent manner. DDO-7263 alone has no significant decrease on cell survival rate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: PC12 cells Concentration: 20 μM Incubation Time: 2, 4, 8, 12, 24 hours Result: Upregulated the protein levels of HO-1 and NQO1 in concentration-dependent manners.
In Vivo
DDO-7263 (10-100 mg/kg/day; IP; for 10 days) improves the behavioral abnormalities induced by MPTP in mice, significantly attenuates chemically induced dopaminergic neuron loss of tyrosine hydroxylase (TH) in the substantia nigra (SN) and striatum of the mouse brain and inhibits the secretion of inflammatory factors . DDO-7263 (7, 35, 70 mg/kg; IP) has a T 1/2 of 3.32 hours and a C max of 1.38 mg/mL for rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6 mice at 10 weeks of age and body weights of 22-26 g Dosage: 10, 50, 100 mg/kg Administration: IP; daily for 10 days Result: Improved the reduction of vertical spontaneous activity and mitigated the loss of balance coordination caused by MPTP (20 mg/kg/day; 7 days). Protected dopaminergic neurons from MPTP. Significantly downregulated the levels of pro-inflammatory factors, including IL-1β and TNF-α, in mouse plasma. Animal Model: SD rats Dosage: 7, 35, 70 mg/kg (Pharmacokinetic Analysis) Administration: IP Result: Had a T 1/2 of 3.32 hours and a C max of 1.38 mg/mL.
Form:Solid
规格
规格或纯度
≥99%
英文名称
DDO-7263
生化机理
DDO-7263是一种1,2,4-恶二唑衍生物，是一种强效的Nrf2-ARE激活剂。DDO-7263 通过与 Rpn6 结合阻断 26S 蛋白酶体的组装以及随后泛素化 Nrf2 的降解来上调 Nrf2。DDO-7263 可诱导 Nrf2 在以下细胞中转位
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激活剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
273.24
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 17.86 mg/mL (65.36 mM; ultrasonic and warming and heat to 60°C)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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