计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
DS89002333 is an orally active and potent PRKACA inhibitor, with an IC 50 of 0.3 nM. DS89002333 shows good anti-tumor activity in an FL-HCC patient-derived xenograft model (expressing the DNAJB1-PRKACA fusion gene). DS89002333 can be used in study of fibrolamellar hepatocellular carcinoma (FL-HCC)
In Vitro
DS89002333 (0.001, 0.01, 0.1, 1, 10 µM; 30 min) inhibits phosphorylation of CREB in a dose-dependent manner in NIH/3T3 cells (phosphorylation status of CREB as a marker of intracellular PRAKACA inhibitory activity). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NIH/3T3 cells Concentration: 0.001, 0.01, 0.1, 1, 10 µM Incubation Time: 30 min Result: Showed a dose-dependent decrease in phosphorylation of CREB, with an IC 50 of 50 nM.
In Vivo
DS89002333 (12.5, 50 mg/kg; p.o.; twice daliy for 5 days) shows anti-tumor activity in an NIH/3T3-fusion allograft model . DS89002333 (3, 30 mg/kg; p.o.; twice daliy for 22 days) shows significant anti-tumor activity in FL-HCC PDX xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female nude mice (NIH/3T3-fusion allograft model) . Dosage: 12.5, 50 mg/kg Administration: Oral administration, twice daliy for 5 days. Result: Exhibited anti-tumor activity without body weight loss. Animal Model: Female NOD SCID mice (FL-HCC PDX xenograft model) . Dosage: 3, 30 mg/kg Administration: Oral administration, twice daliy for 22 days. Result: Significant inhibited tumor in mice, and showed temporary body weight loss (at 30 mg/kg), but this resolved following continuous dosing.
Form:Solid
IC50& Target:PRKACA 0.3 nM (IC 50 )
规格
规格或纯度
≥99%
英文名称
DS89002333
生化机理
DS89002333 是一种具有口服活性的强效 PRKACA 抑制剂，其 IC 50 为 0.3 nM。DS89002333 在 FL-HCC 患者异种移植模型（表达 DNAJB1-PRKACA 融合基因）中显示出良好的抗肿瘤活性。DS89002333 可用于研究纤维蛋白瘤的抗肿瘤活性。
储存条件
2-8°C储存,避光,干燥
运输条件
低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
447.86
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 100 mg/mL (223.28 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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