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Deoxypodophyllotoxin
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule , has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis. Deoxypodophyllotoxin induces cell autophagy and apoptosis . Deoxypodophyllotoxin evokes increase of intracellular Ca 2+ concentrations in DRG neurons .
In Vitro
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Induced apoptosis in SGC-7901 Cells. Cell Cycle AnalysisCell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Induced G2/M cell cycle arrest in SGC-7901 Cells Western Blot AnalysisCell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins.
In Vivo
Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells Dosage: 5, 10, and 20 mg/kg Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days Result: Inhibited the growth of gastric cancer tumors.
规格
别名
脱氧鬼臼毒素
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Deoxypodophyllotoxin
生化机理
脱氧鬼臼毒素（DPT）是鬼臼毒素（podophyllotoxin）的一种衍生物，是一种木质素，具有强效的抗沉迷、抗炎和抗病毒特性。脱氧豆荚毒素以微管为靶标，对肿瘤细胞有重大影响。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
Isomeric SMILES
COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@@H](CC4=CC5=C(C=C24)OCO5)COC3=O
PubChem CID
分子量
398.41
技术文档
高级数据
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技术文档和文章
溶液计算器
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