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Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax , Bcl-2 ; activates caspase-7 , caspase-8 , and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and a
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In Vitro:Dehydrocorydaline hydroxyl (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline hydroxyl. Dehydrocorydaline hydroxy
In Vivo:Dehydrocorydaline hydroxyl manifests a low acute toxicity with an LD 50 of about 277.5±19.0mg/kg body weight in mice following oral administration and 21.1±1.4mg/kg for intraperitoneal injection. MCE has not independently confirmed the accuracy of
Biological Activity:Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax , Bcl-2 ; activates caspase-7, caspase-8 , and inactivates PARP . Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-c