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Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor . Dynorphin A (1-10) (TFA) also blocks NMDA -activated current with an IC 50 of 42.0 μM.
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IC50& Target:NMDA Receptor κ Opioid Receptor/KOR
In Vitro:Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds in the transmembrane domain of the κ-receptor. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated
Biological Activity:Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor . Dynorphin A (1-10) (TFA) also blocks NMDA -activated current with an IC 50 of 42.0 μM.