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Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC 50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the adaptive i
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IC50& Target:TLR1 TLR2
In Vitro:Diprovocim-X stimulates release of TNF-α from (human) differentiated THP-1 cells proves dependent on both TLR2 and TLR1, but notably independent of TLR6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological Activity:Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC 50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the adaptive i