计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 2 篇同行评审文献引用。
概述
Emtricitabine 是一种核苷逆转录酶抑制剂，IC50为27.7 μMA HIV-1 reverse transcriptase (HIV-1 RT) inhibitor
Information
Emtricitabine (BW 1592) Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
In vitro
Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus tenofovir slightly reduced cell proliferation without affecting mitochondrial parameters. Emtricitabine efficiently converts to their active metabolites in PBMCs and CEM cells. Emtricitabine combined with Tenofovir displays additive to synergistic activity against HIV replication in PBMCs and results in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus. Emtricitabine demonstrates antiviral activity against laboratory adapted strains of HIV-1 and HIV-2 in various cell system. Emtricitabine also exhibits antiviral activity in cell culture against feline and simian immuno-deficiency viruses (SIVs). Emtricitabine consistently exhibits up to 10-fold greater activity than lamivudine against all viruses tested in all T-cell lines. Emtricitabine generally demonstrates greater potency in vitro in human PBMCs than in MT-4 lines. Emtricitabine also exhibits anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to the anti-HBV activity of 3TC. Emtricitabine is approximately fourfold more active than 3TC in assays in the transformed T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are equally active against a panel of eight primary HIV-1 isolates from antiretroviral-naive subjects in PBMCs.
In vivo
Cell Data
cell lines：Erythroid cells
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
FTC | 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Emtricitabine (BW 1592)
生化机理
恩曲他滨（BW1592，FTC）是一种新型核苷类药物，对人类免疫缺陷病毒（HIV）和乙型肝炎病毒都有活性。它是一种逆转录酶抑制剂。细胞内半衰期为 39 小时。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
作用机制
人体免疫缺陷病毒 1 型逆转录酶抑制剂
名称和识别符
EC号
604-363-1
分子类型
小分子
Isomeric SMILES
C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F
分子量
247.25
Reaxy-Rn
11732976
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11732976&ln=
技术文档
高级数据
化学和物理性质
比旋光度
-140° (C=0.25,MeOH)
熔点
155 °C
安全和危险性（GHS）
Merck Index
3565
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）