计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,充氩。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC 50 value of 2 uM
In Vitro
EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A549 cells Concentration: 10 μM; 100 μM; 1000 μM Incubation Time: 48 hours Result: Inhibited A549 cells survival.
In Vivo
EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: SCID mice with A549 cells Dosage: 50 mg/kg Administration: Intraperitoneal injection; 50mg/kg; from 14 days; once per day Result: Had strong anti-tumorigenic effects in tumor xenografts.
Form:Oil
IC50& Target:IC50: 2 uM (ALDH3A1)
规格
规格或纯度
≥99%
英文名称
EN40
生化机理
EN40 是一种强效、选择性的醛脱氢酶 3A1 (ALDH3A1) 共价配体抑制剂，其 IC 50 值为 2 uM
储存条件
2-8°C储存,充氩
运输条件
低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
IUPAC Name
1-[5-(furan-2-yl)-4-methyl-3,6-dihydro-2H-pyridin-1-yl]prop-2-en-1-one
INCHI
1S/C13H15NO2/c1-3-13(15)14-7-6-10(2)11(9-14)12-5-4-8-16-12/h3-5,8H,1,6-7,9H2,2H3
InChi Key
UYNKILJNUUDFFJ-UHFFFAOYSA-N
Smiles
CC1=C(CN(CC1)C(=O)C=C)C2=CC=CO2
PubChem CID
分子量
217.26
技术文档
高级数据
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : 5 mg/mL (23.01 mM; Need ultrasonic) Ethanol : 2 mg/mL (9.21 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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