计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4) P 2 phosphatase and Ins(1,4,5) P 3 5-phosphatase . EWP 815 also inhibits enzyme dopamine β-hydroxylase activity
In Vitro
EWP 815 inhibits thyrotropin-releasing hormone (TRH; 0.03 mM)-stimulated inositol phospholipid breakdown without affecting basal breakdown rates in prelabelled GH 3 cells with IC 50 s of 83 mM (soluble enzymes) and 71 mM (particulate enzymes), respectively. EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4) P 2 phosphatase rather than Ins(1,4,5) P 3 5-phosphatase with the mean [ 3 H]Ins(1,4) P 2 /mean [ 3 H]Ins P recovery ratio of 2.6. EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [ 3 H]Ins(1,4,5) P 3 5-phosphatase in particulate and soluble fractions with IC 50 s of 6 μM and 8 μM, respectively. EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5) P 3 binding. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female mice (20 g)Dosage: 50 mg/kg Administration: Intraperitoneal injection; 30 min before killed Result: Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3 H-α-methyldopamine. Reduced the amount of 3 H-α-Me-NA by 12%.
Form:Solid
IC50& Target:Ins(1,4)P2 phosphatase,Ins(1,4,5)P3 5-phosphatase, ,dopamine β-hydroxylase
规格
规格或纯度
≥98%
英文名称
EWP 815
生化机理
EWP 815 是一种双硫仑类似物，是 Ins(1,4) P 2 磷酸酶和 Ins(1,4,5) P 3 5-磷酸酶的强效抑制剂。EWP 815 还能抑制多巴胺 β- 羟化酶的活性。
储存条件
2-8°C储存,避光
运输条件
低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
技术文档
高级数据
关联靶点（人）
MGLL
Tchem
单甘油酯脂肪酶(Monoglyceride lipase)
(2 活性数据)
ALDH2
Tclin
Aldehyde dehydrogenase
(509 活性数据)
FBP1
Tchem
Fructose-1,6-bisphosphatase
(1199 活性数据)
MCF7
(126967 活性数据)
T47D
(39041 活性数据)
MDA-MB-231
(73002 活性数据)
MGLL
Tchem
Monoglyceride lipase
(1909 活性数据)
关联靶点（其它种属）
Faah
Anandamide amidohydrolase (3907 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
DMSO : 50 mg/mL (142.62 mM; Need ultrasonic)
分子量
350.600 g/mol
XLogP3
1.300
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
6
可旋转键计数Rotatable Bond Count
3
精确质量Exact Mass
350.073 Da
单同位素质量Monoisotopic Mass
350.073 Da
拓扑极表面积Topological Polar Surface Area
128.000 Ų
重原子数Heavy Atom Count
20
形式电荷Formal Charge
0
复杂度Complexity
315.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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