计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
EIDD-2749 (4'-Fluorouridine) is an orally active RdRp inhibitor. EIDD-2749 effectively blocks the replication of RSV and SARS-CoV-2 . EIDD-2749 also exhibits activity against HCV and lymphocytic choriomeningitis virus ( LCMV ). EIDD-2749 is a promising oral therapeutic candidate for COVID-19 and is also suitable for research on other RNA viruses
In Vitro
EIDD-2749 induces a delayed stalling of phosphodiester bond formation by RSV and SARS-CoV-2 RdRP. EIDD-2749 is rapidly anabolizes, metabolically stable, and potently antiviral in disease-relevant well-differentiated HAE cultures. EIDD-2749 shows a ≥17-fold increase in anti-RSV potency relative to that on HEp-2 cells; however, the low cytotoxicity levels remains unchanged (CC 50 169 mM), resulting in a high SI (SI = EC 50 /CC 50 ) of ≥1877. EIDD-2749 inhibits SARS-CoV-2 with an EC 50 value of 0.2-0.6 M. EIDD-2749 has an EC 50 of 1.86 μM in theVero E6 cell line, cytotoxicity with a CC 50 of 380 μM, and stability in human plasma. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
EIDD-2749 (0.2, 1, 5 mg/kg; p.o.; single daily for 4 days) shows good orally efficacious in RSV infection mice model in a dose-dependent manner . EIDD-2749 shows high efficacious to SARS-CoV-2 infection and is effective with a single daily dose versus molnupiravir administered twice daily in vivo. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Balb/cJ mice (RSV infection model) . Dosage: 0.2, 1, 5 mg/kg Administration: Oral administration; single daily for 4 days Result: Resulted in a statistically significant reduction in lung virus load.
Form:Solid
IC50& Target:RdRp, RSV,SARS-CoV-2, HCV, COVID-19, LCMV, .
规格
规格或纯度
≥99%
英文名称
EIDD-2749
生化机理
EIDD-2749（4'-氟尿嘧啶）是一种口服活性 RdRp 抑制剂。EIDD-2749 能有效阻断 RSV 和 SARS-CoV-2 的复制。EIDD-2749 还具有抗 HCV 和淋巴细胞性脉络膜炎病毒（LCMV）的活性。EIDD-2749 是一种很有前途的或
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
262.19
技术文档
高级数据
化学和物理性质
溶解性
H2O : 62.5 mg/mL (238.38 mM; Need ultrasonic) DMSO : 25 mg/mL (95.35 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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