计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-20°C储存,干燥。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC 50 s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3 , TLR4 and TLR9 . Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo . Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research
In Vitro
Enpatoran hydrochloride (0.01 nM-10 μM) inhibits production of IL-6 stimulated by all the ligands (miR-122, Let7c RNA, Alu RNA, and R848) with IC 50 values ranging from 35 to 45 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pre-treatment with Enpatoran hydrochloride (oral gavage; 1 mg/kg) before R848 (intraperitoneal injection of 25 µg) dose-dependently inhibits the production of IL-6 and IFN-α in mice . Enpatoran hydrochloride exhibits high oral bioavailability (mouse 100%, rat 87%, dog 84%) following oral administration (mouse, rat and dog 1.0 mg/kg) . Enpatoran hydrochloride exhibits moderate half-lives (mouse 1.4, rat 5.0 and dog 13 h) due to high plasma clearance (1.4, 1.2 and 0.59 L/h/kg, respectively) combined with large volumes of distribution (2.7, 8.7 and 5.7 L/kg, respectively) following intravenous administration (mouse, rat and dog 1.0 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 mice Dosage: 0.1 mg/kg and 1 mg/kg Administration: Oral gavage; administered 1 hour prior to R848 challenge Result: The TLR7/8 agonist R848 stimulated both IFN-α and IL-6 production in mice. Enpatoran hydrochloride decreased IFN-α and IL-6 production stimulated by R848.
Form:Solid
IC50& Target:TLR7 11.1 nM (IC 50 ) TLR8 24.1 nM (IC 50 )
规格
别名
盐酸恩帕托兰
规格或纯度
≥98%
英文名称
Enpatoran hydrochloride
生化机理
盐酸恩帕他坦（M5049）是一种强效的口服活性 TLR7/8 双重抑制剂，在 HEK293 细胞中的 IC 50 s 分别为 11.1 nM 和 24.1 nM。盐酸恩帕他兰对 TLR3、TLR4 和 TLR9 没有活性。盐酸恩帕坦可阻断
储存条件
避光,-20°C储存,干燥
运输条件
超低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
356.77
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 16.67 mg/mL (46.72 mM; ultrasonic and warming and heat to 60°C)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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