计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,充氩,干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Endomorphin 1 acetate, a high affinity, highly selective agonist of the μ-opioid receptor ( K i : 1.11 nM), displays reasonable affinities for kappa 3 binding sites, with K i value between 20 and 30 nM. Endomorphin 1 acetate has antinociceptive properties.
In Vitro
Endomorphin 1 acetate inhibits Forskolin (1 μM) stimulated cyclic AMP formation with a pIC 50 value of 8.03 in In CHOμ cells . Endomorphin 1 (1-10 μM) acetate increases interleukin-8 secretion in Caco-2 cells. Endomorphin 1 (1 μM) acetate inhibits excitatory transmission in adult rat substantia gelatinosa neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Endomorphin 1 (i.c.v.) acetate shows antinociceptive properties in mice, with an ED 50 value of 6.16 nM. Endomorphin 1 (50 μg/kg, i.v., rats) acetate alleviates myocardial ischemia/reperfusion injury (MIRI) by inhibiting the inflammatory response. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: ICR mice. Dosage: 6.16 nM (ED 50 ) Administration: Intracerebroventricularly (i.c.v.) injection Result: Inhibited dose-dependently the tail-flick response. Animal Model: Rats. Dosage: 50 μg/kg Administration: Intravenously following LAD ligation for 25 min, subsequently the LAD was reperfused for 120 min. Result: Alleviated MIRI by reducing the production of free radicals. Dncreased LDH and CK-MB activities. Increased SOD activity and decreased MDA content. Decreased IL-6 and TNF-α plasma content.
Form:Solid
IC50& Target:μ Opioid Receptor/MOR 1.11 nM (Ki)
规格
别名
内吗啡肽-1醋酸盐
规格或纯度
≥99%
英文名称
Endomorphin 1 acetate
生化机理
醋酸恩多吗啡 1 是一种高亲和力、高选择性的μ-阿片受体激动剂（K i：1.11 nM），对卡帕 3 结合位点具有合理的亲和力，K i 值介于 20 至 30 nM 之间。醋酸内多啡肽 1 具有抗痛觉特性
储存条件
避光,充氩,干燥,-80℃储存
运输条件
特低温运输
作用类型
激动剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
670.75
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 125 mg/mL (186.36 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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