计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,干燥。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor , with K i s of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (K i =0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity
In Vitro
Ecopipam (2 μM) hydrobromide completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ecopipam (10, mg/kg, oral administration) antagonizes Apomorphine-induced stereotypy in rats. Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male young adult Long-Evans rats were injected with NicotineDosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg) Result: Dose-dependently reduced pressing on both active and inactive levers.
Form:Solid
IC50& Target:D 1 Receptor 1.2 nM (Ki) D 5 Receptor 2.0 nM (Ki) D 2 Receptor 980 nM (Ki) D 4 Receptor 5520 nM (Ki) 5-HT Receptor 80 nM (Ki) Alpha-2A adrenergic receptor 731 nM (Ki)
规格
别名
氢溴酸依可匹泮
规格或纯度
≥99%
英文名称
Ecopipam hydrobromide
生化机理
氢溴酸依可比泮（SCH 39166）是一种强效、选择性和口服活性的多巴胺 D1/D5 受体拮抗剂，其 K i 分别为 1.2 nM 和 2.0 nM。氢溴酸依可匹仑对 D2、D4、5-羟色胺和 α2a 受体的选择性超过 40 倍。
储存条件
-20°C储存,干燥
运输条件
超低温运输
作用类型
拮抗剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
394.73
技术文档
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
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溶液计算器
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