计算溶液所需的质量、体积或浓度。
铁氧还蛋白-NADP还原酶 (FDXR) (ADR,NADPH:肾上腺铁氧还蛋白氧化还原酶,EC 1.18.1.6)是单体黄素酶,含有FAD辅基,分子量约51kDa,几乎参与了人体内几乎所有的类固醇激素的生物合成。
哺乳动物线粒体P450单加氧酶系统由NADPH依赖的皮质铁氧还蛋白还原酶(ADR)、皮质铁氧还蛋白(ADX),和线粒体P450组成。在这个电子传递链中,电子由NADPH通过ADR和ADX转移到线粒体P450 。
在细胞色素P450scc催化胆固醇结构中C-22和C-20位的羟基化, 然后裂解它们之间的碳链, 形成孕烯醇酮过程中,每一催化步骤,都有2对电子由NADPH 通过皮质铁氧还原蛋白及其还原酶转运至细胞色素P450scc。
参与甾类激素合成。
Ferredoxin-NADP⁺ reductase (FDXR), also known as ADR or NADPH:adrenodoxin oxidoreductase (EC 1.18.1.6), is a monomeric flavoenzyme containing a FAD prosthetic group, with a molecular weight of approximately 51 kDa. It participates in the biosynthesis of almost all steroid hormones in the human body.
The mammalian mitochondrial P450 monooxygenase system consists of NADPH-dependent adrenodoxin reductase (ADR), adrenodoxin (ADX), and mitochondrial P450. In this electron transport chain, electrons are transferred from NADPH to mitochondrial P450 via ADR and ADX.
During the hydroxylation of cholesterol at C-22 and C-20, followed by side-chain cleavage to form pregnenolone catalyzed by cytochrome P450scc, two pairs of electrons are delivered from NADPH to cytochrome P450scc via adrenodoxin and its reductase in each catalytic cycle.
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