| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F408131-1ml |
1ml |
现货  |
|
| 英文别名 | SCH-13521 | 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Flutamide |
| 生化机理 | 氟他胺（SCH-13521）是一种抗雄激素药物，其活性代谢物与雄激素受体结合的Ki值为 55 nM，主要用于治疗前列腺癌。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | 雄激素受体拮抗剂 |
| 产品介绍 |
Flutamide is an androgen receptor inhibitor with chemopreventive properties against bladder and prostate carcinogenesis. Flutamide inhibits the expression of testosterone regulated transforming growth factor β-1 (TGF-β1).An androgen receptor antagonist Information Flutamide Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with K i values of 55 nM, and primarily used to treat prostate cancer. Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide. In vivo Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity. cell lines： Concentrations：~1 μM Incubation Time：40 days Powder Purity:≥99% |
| ALogP | 2.916 |
|---|---|
| hba_count | 1 |
| HBD Count | 1 |
| Rotatable Bond | 4 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F |
| 分子量 | 276.21 |
| Reaxy-Rn | 2157663 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2157663&ln= |
| DMSO(mg / mL) Max Solubility | 55 |
|---|---|
| DMSO(mM) Max Solubility | 199.12 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 2157663 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2157663&ln= |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
| Record the entire process by video | Conform |
| 1. Jiao Sha, Kaibo Hu, Tingting Li, Zidan Cao, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2021) Solubility determination, model correlation, solvent effect, molecular simulation and thermodynamic properties of flutamide in eleven pure solvents at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 336 (115559). [10.1016/j.molliq.2021.115559] |
| 1. Jiao Sha, Kaibo Hu, Tingting Li, Zidan Cao, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2021) Solubility determination, model correlation, solvent effect, molecular simulation and thermodynamic properties of flutamide in eleven pure solvents at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 336 (115559). [10.1016/j.molliq.2021.115559] |
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