FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 ( FLT3 ; IC 50 =7 nM) inhibitor for treating acute myelogenous leukemia.
In Vitro
FLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC 50 values are 0.089±0.001 nM and 0.022±0.003 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.