计算溶液所需的质量、体积或浓度。
概述
F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress
In Vitro
F13714 targets 5-HT1A autoreceptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels . F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5% . F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement . F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:5-HT 1A Receptor
规格
别名
F 13714 富马酸盐
规格或纯度
≥98%
英文名称
F 13714 fumarate
生化机理
富马酸 F13714 是一种选择性 5-HT1A 受体偏向激动剂，在慢性轻度应激小鼠模型中单次给药后显示出类似抗抑郁的特性。
储存条件
2-8°C储存,干燥
运输条件
低温运输
作用类型
激动剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
538.97
高级数据
化学和物理性质
溶解性
DMSO : 250 mg/mL (463.85 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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