What Is (S)-1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate?

(S)-1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate (Aladdin SKU B731874) is a chiral piperidine derivative in which the nitrogen is protected as a benzyl carbamate (Cbz group) and the C-3 position carries an ethyl ester with defined (S)-absolute configuration. The molecule belongs to the class of N-protected amino acid-type building blocks commonly employed in medicinal chemistry and total synthesis. The Cbz group can be removed selectively by catalytic hydrogenolysis, while the ethyl ester is amenable to saponification or further elaboration, making this compound a versatile synthetic intermediate.

Handling, Storage, and Safety

As with most chiral ester intermediates, (S)-1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate should be stored in a tightly sealed container away from moisture, heat, and light to preserve optical purity and chemical integrity. Standard laboratory precautions apply: use appropriate personal protective equipment (gloves, safety glasses, and lab coat) when handling the compound. Consult the product-specific Safety Data Sheet (SDS) available from Aladdin Scientific for full hazard classification, first-aid measures, and disposal guidance before use.

Note: Specific GHS hazard classifications for this SKU should be confirmed in the SDS; consult Aladdin Scientific customer support or the product page for the most current safety information.

Applications in Synthesis

(S)-1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate serves as a key chiral building block in the synthesis of biologically active piperidine-containing natural products and drug candidates. The orthogonal protecting group strategy—Cbz on nitrogen, ethyl ester on carbon—allows sequential, selective deprotection and functionalization steps. Typical downstream transformations include: (1) Cbz removal via Pd/C-catalyzed hydrogenolysis to liberate the secondary amine for alkylation or acylation; (2) ester hydrolysis to give the free carboxylic acid for peptide coupling or decarboxylative modifications; and (3) reduction of the ester to the corresponding alcohol for further elaboration. Its well-defined (S)-stereocenter is critical for accessing enantiomerically pure target molecules in pharmaceutical research.

Ordering and Availability

(S)-1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate is available from Aladdin Scientific under catalog number B731874. To place an order, visit the Aladdin Scientific website, search by SKU or product name, and add the desired quantity to your cart. For bulk quantities, custom packaging, or certificate of analysis (CoA) requests, contact Aladdin Scientific's sales or customer service team directly. Lead times and available pack sizes may vary; please check the product page for real-time stock status and pricing information.