In asymmetric synthesis, “chiral amines” are one of those high-frequency terms you can hardly avoid. Their value comes from a powerful combination of traits: basicity/coordination ability + reversible formation of key intermediates + easy conversion into diastereomeric salts/derivatives for ...
Professor Karl Anker Jørgensen and his research team have synthesized (R)- and (S)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether compounds, which excel as chiral organocatalysts for the direct and asymmetric α-functionalization process of aldehydes.
BINOL and its derivatives are one of the most widely used types of ligands in asymmetric synthesis; being utilized in a variety of reactions including——Diels-Alder, carbonyl addition and reduction, Michael addition, and a variety of other reactions. Although great success has been achieved using ...