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ActRIIA and ActRIIB are important receptors for TGF-β superfamily ligands such as Myostatin/GDF8 and Activin A. Through SMAD2/3 signaling, they restrict skeletal muscle growth and participate in adipose tissue metabolism. Blocking ActRIIA/ActRIIB can increase or preserve Lean Mass while ...
ActRIIA和ActRIIB是Myostatin/GDF8、Activin A等TGF-β超家族配体的重要受体，通过SMAD2/3信号限制骨骼肌生长并参与脂肪组织代谢。阻断ActRIIA/ActRIIB可增加或保护瘦体重并促进脂肪量下降，使其成为减重过程中改善体成分的重要干预方向。
Activins and inhibins both belong to the TGF-β superfamily and are formed by different combinations of inhibin subunits, but they exert opposing effects on the regulation of pituitary follicle-stimulating hormone (FSH). Activins promote FSH synthesis and secretion, whereas inhibins restrict ...
激活素（activins）和抑制素（inhibins）均属于TGF-β超家族，由不同的抑制素亚基组合形成，但在垂体促卵泡激素（follicle-stimulating ...
Induced pluripotent stem cells (iPSCs) have self-renewal and multilineage differentiation capacities and can be used in disease modeling, drug screening, organoid construction, and cell therapy research. Directed differentiation of iPSCs depends on stage-specific signal regulation. Activin A, ...
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