主题

Small molecule inhibitors

用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。

3 项资源 · 实验方案、常见问题与文章
article

Construction of the Key α-Bromoketone Intermediate for LY3509754: A β-Keto Ester Strategy and Concomitant Decarboxylation Following Enzymatic Ester Hydrolysis

LY3509754 is a small-molecule inhibitor of interleukin-17A (IL-17A). Its synthesis requires a key intermediate containing a 4,4-difluorocyclohexyl group, a chiral amino substituent, and an α-bromoketone moiety. In a 2025 process development study, 110 kg of this α-bromoketone intermediate was ...

更新于 2026年10月阅读12分钟
article

Construction of the Key α-Bromoketone Intermediate for LY3509754: A β-Keto Ester Strategy and Concomitant Decarboxylation Following Enzymatic Ester Hydrolysis

LY3509754 is a small-molecule inhibitor of interleukin-17A (IL-17A). Its synthesis requires a key intermediate containing a 4,4-difluorocyclohexyl group, a chiral amino substituent, and an α-bromoketone moiety. In a 2025 process development study, 110 kg of this α-bromoketone intermediate was ...

更新于 2026年9月阅读12分钟

相关主题

常与免疫学实验一起研究的技术。