LY3509754 is a small-molecule inhibitor of interleukin-17A (IL-17A). Its synthesis requires a key intermediate containing a 4,4-difluorocyclohexyl group, a chiral amino substituent, and an α-bromoketone moiety. In a 2025 process development study, 110 kg of this α-bromoketone intermediate was ...
LY3509754 is a small-molecule inhibitor of interleukin-17A (IL-17A). Its synthesis requires a key intermediate containing a 4,4-difluorocyclohexyl group, a chiral amino substituent, and an α-bromoketone moiety. In a 2025 process development study, 110 kg of this α-bromoketone intermediate was ...
Proteolysis-targeting chimeras (PROTACs) are a class of heterobifunctional molecules that selectively reduce the abundance of a protein of interest by harnessing the cellular ubiquitin–proteasome system (UPS). They represent an important modality within the field of targeted protein degradation ...