Saturated nitrogen-containing heterocyclic ring

One-Pot Arylation of the Piperidine α-C–H Bond: From Directed Lithiation and Li→Zn Transmetalation to Negishi Coupling

Piperidine is a saturated nitrogen-containing heterocycle commonly found in drug molecules. Statistical analyses of the structures of drugs approved in the United States have shown that piperidine occurs at a relatively high frequency among nitrogen-containing heterocycles in pharmaceuticals ...