一级、二级胺为何难以直接参与经典Mitsunobu反应：BEHT介导醇胺化的机理、构型翻转与反应范围
经典Mitsunobu反应能够在较温和条件下活化醇，并通过亲核取代形成新的C—N、C—O或C—S键。对于适当的手性仲醇，反应通常伴随构型翻转。该反应因此广泛用于天然产物、药物分子和手性中间体的合成。[2,3]
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BEHT
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2 项资源 · 实验方案、常见问题与文章
Why Primary and Secondary Amines Have Difficulty Participating Directly in the Classical Mitsunobu Reaction: Mechanism, Inversion of Configuration, and Reaction Scope of BEHT-Mediated Alcohol Amination
The classical Mitsunobu reaction can activate alcohols under relatively mild conditions and form new C—N, C—O, or C—S bonds through nucleophilic substitution. With suitable chiral secondary alcohols, the reaction is generally accompanied by inversion of configuration. It is therefore widely used ...
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