Molecular Composition, Signal Transduction Mechanisms, and Targeted Regulatory Strategies of the Hippo Signaling Pathway
The Hippo signaling pathway is a cell-state sensing system centered on the MST/MAP4K-LATS kinase network, with YAP/TAZ-TEAD serving as its major transcriptional output. Unlike classical signaling pathways with fixed ligands and receptors, Hippo integrates multiple inputs, including cell contact, ...
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