从PROTAC到非泛素-蛋白酶体降解：LYTAC、ATTEC、AUTAC与BacPROTAC的机制与选择
经典PROTAC依赖E3泛素连接酶和蛋白酶体清除胞内靶蛋白，但难以覆盖胞外蛋白、大尺度细胞组分及细菌蛋白。LYTAC、ATTEC、AUTAC和BacPROTAC分别利用内吞-溶酶体、自噬-溶酶体或原核蛋白酶系统，为不同空间位置和物理尺度的靶标建立定向清除途径。 ...
主题
AUTAC
以下是知识库中与该主题相关的实验方案、常见问题、指南与技术文章。
4 项资源 · 实验方案、常见问题与文章
From PROTAC to Non-Ubiquitin–Proteasome Degradation: Mechanisms and Selection of LYTAC, ATTEC, AUTAC, and BacPROTAC
Classical PROTACs rely on E3 ubiquitin ligases and the proteasome to eliminate intracellular target proteins, but they are difficult to apply to extracellular proteins, large-scale cellular components, and bacterial proteins. LYTAC, ATTEC, AUTAC, and BacPROTAC respectively utilize ...
AUTAC or AUTOTAC? Mechanistic Differences Between First- and Second-Generation Autophagy-Targeting Degradation Technologies
Targeted protein degradation is expanding from the ubiquitin-proteasome system to the autophagy-lysosome system. AUTAC, AUTOTAC, and ATTEC can all exploit autophagy to eliminate specific targets, but they differ in cargo recognition and autophagy-recruitment mechanisms. First- and ...
AUTAC还是AUTOTAC？第一代、第二代自噬靶向降解技术的机制差异
靶向蛋白降解正在从泛素-蛋白酶体系统扩展至自噬-溶酶体系统。AUTAC、AUTOTAC和ATTEC均可利用自噬实现靶标清除，但三者的货物识别与自噬募集机制不同；第一代与第二代AUTAC则属于同一技术路线的结构优化。
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