Nucleic acid molecules such as mRNA and siRNA are susceptible to nuclease degradation, cannot readily cross cell membranes, and may become trapped within endosomes after endocytosis. Lipid nanoparticles (LNPs) establish a cytosolic delivery pathway through nucleic acid encapsulation, ...
Lipids are not synonymous with fats. Fats mainly refer to energy-storage lipids such as triacylglycerols, whereas lipids comprise a much broader range of structural classes, including fatty acids, glycerophospholipids, sphingolipids, and sterol lipids. Different lipids participate not only in ...