从 DENV-2 筛选命中到四血清型覆盖：JNJ-1802 的泛血清型构效关系优化
登革病毒（dengue virus，DENV）主要包括 DENV-1、DENV-2、DENV-3 和 DENV-4 ...
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DENV-2
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From a DENV-2 Screening Hit to Coverage of All Four Serotypes: Pan-Serotype Structure–Activity Relationship Optimization of JNJ-1802
Dengue virus (DENV) mainly comprises four serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. All four serotypes can cause dengue virus infection, but their viral protein sequences are not identical, and the inhibitory activity of the same small molecule may differ substantially among serotypes. ...
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